IGF-DES (Desmethoxy-IGF-I) – 2MG

IGF-DES, or desmethoxy-insulin-like growth factor 1 (Desmethoxy-IGF-I), is a synthetic derivative of IGF-I designed for research applications in biochemical, cellular, and molecular biology studies. This product is provided as a research tool to support investigations into growth factor signaling pathways, cellular proliferation, and metabolic regulation under controlled laboratory conditions.

Research Context

IGF-1 is a key anabolic hormone involved in growth, development, and metabolism. Desmethoxy-IGF-I differs from native IGF-I by the absence of a methoxy group on one of its tyrosine residues, which can influence its binding affinity to IGF-1 receptors and subsequent downstream signaling outcomes. This structural modification is frequently employed in research to explore the functional differences between native and modified IGF variants in various biological contexts.

Research Overview

IGF-DES serves as a valuable research reagent for investigating the functional roles of IGF-I signaling in cell biology, pharmacology, and regenerative medicine. Its structural modifications allow researchers to probe specific interactions between IGF variants and receptor binding domains, cellular responses to growth factors, and potential therapeutic or toxicological effects under research settings.

Key Research Focus Areas

• Investigating receptor binding kinetics and specificity between IGF-I derivatives and IGF-1 receptors.
• Analyzing the effects of IGF-DES on cell cycle progression, proliferation, and differentiation in vitro.
• Studying metabolic regulation and insulin-like growth factor signaling in disease models or cellular assays.
• Exploring potential applications in pharmacological research, including potential modifications for enhanced stability or target specificity.
• Assessing cytotoxic or proliferative effects in pre-clinical or toxicological studies.

Important Safety and Compliance Notice

This product is intended solely for research purposes and is not approved for human or animal consumption, therapeutic use, or any commercial application. The handling, storage, and disposal of this material must adhere to all applicable laboratory safety protocols, including proper documentation, waste management, and compliance with local regulations. Researchers must conduct all experiments under the supervision of qualified personnel and in compliance with institutional guidelines. Any deviations from these instructions may result in improper use and potential hazards.

For research use only. Not for human or animal consumption.